No, he could not KO Cain in a bout. He has the chance, but Cain would have him on the ground with his superior wrestling ability. They are too big, the Klitchkos. They would not be able to handle the MMA style of fighting. They are good "boxers" . That's it.

Cain by TKO RD. 1 Ground, and Pound

Whlad hits hard, but is slow, and has no take down defense. Cain would take him down , control him easily, and smash him.

I'm not saying Boxers, can't be successful in MMA. The boxer better hit extremely hard, and fast, and have some sort of take down defense. I feel a Prime Tyson would of had a much better chance in MMA, then the Klitschko's

Cain could beat any heavyweight boxer alive right now easily. He's too strong and an elite wrestler.

not in a cage no.

In the heavyweight division in MMA the fighters like Cain and DC, smother their opponenets against the cage and wear them out, mixing it up with dirty boxing like u saw against JDS. This grind is very effective

In boxing , the klitsxhkos are the best at tying up their opponents and leaning all their huge bodyweight onto them, tiring them out before picking them apart. Klitschos do this without the huge benefit of a fence onto which to push their opponent against.

With small gloves, vitali could KO his opponenets with jabs, as he has done with bigger padded gloves in boxing. With 6months of solid takedown defence training , I think the klitsxhkos could clean up the heavyweight division with ease.

What do you think?

ps. No angry answers, I am a fan of both MMA and boxing.